Maternal Intake and Polyphenols
ثبت نشده
چکیده
OBJECTIVE: To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring. METHODS: Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding the mothers' diet during pregnancy, were completed after delivery. Follow-up of the children (questionnaires and blood sampling) was performed at 1, 2.5 and 5 yr of age. IA was defined as being positive (above the 95th percentile for healthy children) in two or more measurements of autoantibodies [glutamic acid decarboxylase (GADA); tyrosine phosphatase (IA-2A), insulin autoantibodies (IAA)] analysed at the three time points or being diagnosed with type 1 diabetes during the 5-yr follow-up period. The 5 724 children in whom we carried out two to three possible blood samplings were included in the study. Logistic regression analysis was used to identify variables predicting IA. RESULTS: Of 5 724 children,191 (3.3%) were considered positive for IA. In a univariate analysis, less than daily consumption of vegetables (3-5 times/week) in the mothers' diet was associated with increased risk of IA (OR 1.71, 95% CI:1.24-2.35, p = 0.001) compared to daily consumption (p for trend = 0.004). The association was strengthened when adjusting for known IA-risk factors (p for trend <0.001). CONCLUSIONS: Daily consumption of vegetables in the mothers' diet during pregnancy was associated with a decreased risk of IA in the offspring. PMID: 19761530 [PubMed in process] Supplemental Content Food Chem Toxicol. 2007 Jan;45(1):64-9. Epub 2006 Aug 7. A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats. Ganiger S, Malleshappa HN, Krishnappa H, Rajashekhar G, Ramakrishna Rao V, Sullivan F. Toxicology Department, Rallis Research Centre, Rallis India Limited, Post Box No. 5813, Plot Nos. 21 and 22, Peenya II Phase, Bangalore 560 058, India.
منابع مشابه
Deleterious effects of maternal ingestion of cocoa upon fetal ductus arteriosus in late pregnancy
Cocoa powder has twice more antioxidants than red wine and three times more than green tea. Ten percent of its weight is made up of flavonoids. Cocoa has antioxidant and anti-inflammatory effects by downregulating cyclooxigenase-2 receptors expression in the endothelium and enhancing nitric oxide bioavailability. There are evidences that while polyphenols ingestion have cardioprotective effects...
متن کاملDiet and asthma: nutrition implications from prevention to treatment.
Asthma is characterized by lung airway inflammation initiated and perpetuated by an inappropriate immune response, increased airway responsiveness, and variable airflow obstruction. In Western countries there has been a marked increase in asthma prevalence such that it has become a public health concern. It has been hypothesized that the increase may be due to changing antioxidant intake, incre...
متن کاملPolyphenols in your diet may regulate food intake Role of dietary polyphenols in food intake Frontier Voice of Nutrition Remarks (May 06, 2013)
متن کامل
Estimated Dietary Polyphenol Intake and Major Food and Beverage Sources among Elderly Japanese
Estimating polyphenol intake contributes to the understanding of polyphenols' health benefits. However, information about human polyphenol intake is scarce, especially in the elderly. This study aimed to estimate the dietary intake and major sources of polyphenols and to determine whether there is any relationship between polyphenol intake and micronutrient intake in healthy elderly Japanese. F...
متن کاملMaternal Restriction of Polyphenols and Fetal Ductal Dynamics in Normal Pregnancy: An Open Clinical Trial
BACKGROUND We have recently demonstrated reversal of fetal ductal constriction after dietary maternal restriction of polyphenol-rich foods (PRF), due to its inhibitory action on prostaglandin synthesis. OBJECTIVE To test the hyphotesis that normal third trimester fetuses also improve ductus arteriosus dynamics after maternal restriction of polyphenols. METHODS Open clinical trial with 46 fe...
متن کاملDietary intake and major food sources of polyphenols in Finnish adults.
Phenolic acids, flavonoids, proanthocyanidins, and ellagitannins are polyphenols that may have beneficial effects on human health and provide protection against chronic diseases. To date, limited data exist on quantitative intake of polyphenols. The aims of this study were to estimate the quantitative intakes of polyphenols by using analyzed concentrations together with individual food consumpt...
متن کامل